A novel and efficient synthesis of 1, 2, 3,4-tetrahydropyrimidine carboxamide derivatives by Biginelli reaction and their in vitro antibacterial activity

Introduction and Aim: An efficient aspect of two step synthesis tetrahydro pyrimidine carboxamide derivatives were developed by Biginelli reaction. The two-step synthesized 1,2,3,4-tetrahydropyrimidinecarboxamide compounds evaluated In-vitro studies like antifungal bacterial activities. Few shown excellent zone inhibition against fungal Microbial In this study showed significant effect action derivatives. Materials Methods: procedure to synthesize derivatives, ethyl acetoacetate, cytosine, para-toluene sulphonic acid ethanol used. Results: 1,2,3,4-tetrahydropyrimidine through reaction used an catalyst such as solvent ethanol. tested have into protocol for diversely substituted novel pyrimidines. Conclusion: the (THPC) shows inhibiting Gram +ve, –ve growth.